The Heterophilic Blocking Reagent (HBR) allows rapid and simple elimination of false positive heterophilic interference in plasma or serum for sandwich immunoassays.
Figure 1. True positive in a sandwich assay
Figure 2. False positive is a result of heterophilic antibody interference in a sandwich assay
Figure 3.
HBR contains both passive and active blockers which effectively eliminate heterophilic interference
Figure 4. A comparison of HBR with other false positive blockers in the market.
Reference
1. Prevalence of Heterophilic Antibody Interference in Eight Automated Tumor Marker Immunoassays Clinical Chemistry 51,
No. 1, 2005
2. Techniques for Identifying Heterophile Antibody Interference Are Assay Specific: Study of Seven Analytes on Two
Automated Immunoassay Analyzers Clinical Chemistry 51, No. 3, 2005
3. A Hyperthyroid Patient with Measurable Thyroid-stimulating Hormone Concentration – A Trap for the Unwary Annals
Academy of Medicine
